Halima Kholaiq

Conference 2024 Live Talk

Talk Title

COVID-19 disease in children hospitalized at the Pediatric COVID19 Unit of P1, HMEAH – CHU Ibn Rochd – Casablanca: an epidemio-clinical study

Authors and Affiliations

Halima Kholaiq1, Ibtihal Benhsaien1,2, Khaoula Oussama1, Naima Amenzoui1,2, Jalila El Bakkouri1,3, Ahmed Aziz Bousfiha1,2
1. Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
2. Department of Clinical Immunology and Infectious Pediatrics, Abderrahim Harouchi Hospital, CHU Ibn Rochd, Casablanca, Morocco.
3. Laboratory of Immunology, CHU Ibn Rochd, Casablanca, Morocco.

Abstract

Background

Coronavirus 2019 is an emerging infectious disease caused by SARS-CoV-2. Affected patients are adults, children have only a mild disease, they may present MIS-C. The comorbidities may aggravate the disease. The aim is to describe the epidemio-clinical and evolutionary profile of COVID-19 in patients hospitalized in the P1 infectious disease department.

Methods

Our study involved 131 hospitalized children recruited from the department of Pediatric Infectious Diseases and Clinical Immunology, a retrospective study, from March 2019 to October 2021. Analysis of the clinical, paraclinical and therapeutic data were collected from the hospitalization records of patients with positive COVID-19 PCR.

Results

The mean age of patients was 5.3 years (34J±14y), with Sex ratio of 1.1. The most frequent clinical signs were fever 73%, rate 30%, vomiting 23%, diarrhea in 21% of cases, 15% were asymptomatic, 13% nausea and 11% with headache. The comorbidities noted were hematological pathologies in 41.86% of cases. In all, lymphopenia was reported in 47.1% of 47.93% had CRP+ and 22.13% had radiological abnormalities. The clinical presentation was made up of cases of isolated COVID- 19 (37%), COVID-19 and comorbidities (33%) and MIS-C in 30% of cases. The evolution was favorable, with cure in 95.42% of cases, 4.58% of deaths, including 5 with comorbidity 2 Malignant non-Hodgkin
lymphomas (LMNH), 1 Primary immunodeficiency (DIP) and 2 borderline personality disorder (BPD).

Conclusions

These findings demonstrate that Respiratory Isolated, Comorbidity PCR+ and MIS-C are the three aspects that cause SARS-CoV-2 infection in hospitalized children. Male sex is higher than in the literature with a high number of comorbidities. MIS-C initiates life prognosis.